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Efficacy <t>of</t> <t>mHGF</t> versus <t>mNGF</t> treatments in accelerating corneal epithelial wound closure. (A) Representative corneal fluorescein images on day 4 after injury and (B) Kaplan–Meier survival curve analysis showing percentage of corneas with epithelial defect from day 0 to day 7. N = 8 to 10 mice/group.
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Efficacy of mHGF versus mNGF treatments in accelerating corneal epithelial wound closure. (A) Representative corneal fluorescein images on day 4 after injury and (B) Kaplan–Meier survival curve analysis showing percentage of corneas with epithelial defect from day 0 to day 7. N = 8 to 10 mice/group.

Journal: Cornea

Article Title: Topical Hepatocyte Growth Factor Accelerates Wound Healing and Inhibits Scarring in Experimental Corneal Injury

doi: 10.1097/ICO.0000000000003932

Figure Lengend Snippet: Efficacy of mHGF versus mNGF treatments in accelerating corneal epithelial wound closure. (A) Representative corneal fluorescein images on day 4 after injury and (B) Kaplan–Meier survival curve analysis showing percentage of corneas with epithelial defect from day 0 to day 7. N = 8 to 10 mice/group.

Article Snippet: Topical ocular treatments included PBS alone and 0.1% mNGF (murine recombinant nerve growth factor), 0.1% mHGF (murine recombinant hepatocyte growth factor), and 0.1% and 0.2% deleted HGF (dHGF) (a deleted variant of recombinant human hepatocyte growth factor), each formulated in PBS. mHGF (cat# 2207-HG/CF) and mNGF (cat# 1156-NG-100/CF) were obtained from RnD Systems, while dHGF was obtained from Kringle Pharma.

Techniques:

Efficacy of mHGF versus mNGF treatments in inhibiting corneal scar formation. (A) Representative bright-field images showing corneal scars and (B) mean scar sizes on day 7 after injury. Error bars represent standard error of the mean. N = 8 to 10 mice/group.

Journal: Cornea

Article Title: Topical Hepatocyte Growth Factor Accelerates Wound Healing and Inhibits Scarring in Experimental Corneal Injury

doi: 10.1097/ICO.0000000000003932

Figure Lengend Snippet: Efficacy of mHGF versus mNGF treatments in inhibiting corneal scar formation. (A) Representative bright-field images showing corneal scars and (B) mean scar sizes on day 7 after injury. Error bars represent standard error of the mean. N = 8 to 10 mice/group.

Article Snippet: Topical ocular treatments included PBS alone and 0.1% mNGF (murine recombinant nerve growth factor), 0.1% mHGF (murine recombinant hepatocyte growth factor), and 0.1% and 0.2% deleted HGF (dHGF) (a deleted variant of recombinant human hepatocyte growth factor), each formulated in PBS. mHGF (cat# 2207-HG/CF) and mNGF (cat# 1156-NG-100/CF) were obtained from RnD Systems, while dHGF was obtained from Kringle Pharma.

Techniques:

Regression of preexisting corneal scar with topical human recombinant HGF (0.1% and 0.2% dHGF) and 0.1% mHGF compared with 0.1% mNGF and PBS (control). (A) Representative images of scars on day 10 (top panel) and day 21 (lower panel) for each treatment group. (B) Mean percent reduction in preexisting corneal scars from day 8 (baseline) to day 21 or each treatment group. Error bars represent standard error of the mean. N = 8 to 10 mice/group.

Journal: Cornea

Article Title: Topical Hepatocyte Growth Factor Accelerates Wound Healing and Inhibits Scarring in Experimental Corneal Injury

doi: 10.1097/ICO.0000000000003932

Figure Lengend Snippet: Regression of preexisting corneal scar with topical human recombinant HGF (0.1% and 0.2% dHGF) and 0.1% mHGF compared with 0.1% mNGF and PBS (control). (A) Representative images of scars on day 10 (top panel) and day 21 (lower panel) for each treatment group. (B) Mean percent reduction in preexisting corneal scars from day 8 (baseline) to day 21 or each treatment group. Error bars represent standard error of the mean. N = 8 to 10 mice/group.

Article Snippet: Topical ocular treatments included PBS alone and 0.1% mNGF (murine recombinant nerve growth factor), 0.1% mHGF (murine recombinant hepatocyte growth factor), and 0.1% and 0.2% deleted HGF (dHGF) (a deleted variant of recombinant human hepatocyte growth factor), each formulated in PBS. mHGF (cat# 2207-HG/CF) and mNGF (cat# 1156-NG-100/CF) were obtained from RnD Systems, while dHGF was obtained from Kringle Pharma.

Techniques: Recombinant, Control